Two kinds of worries are associated with the politicization and the commercialization of science. These worries concern, first, the nature of the research agenda, and, second, the test and confirmation procedures in science. In both respects, moral as well as epistemological misgivings are brought to bear. Modes of problem selection are criticized on moral grounds by claiming that questions of short-term benefit are emphasized in politicized and commercialized research, while issues that are essential for large parts of humankind are neglected. In methodological respect, one of the relevant arguments is that the dominance of non-epistemic interests tends to induce superficiality and one-sidedness in the process of empirical scrutiny which undermine the high standards of confirmation traditionally associated with science. In the project, these two sorts of worries are intended to be pursued and their import on science assessed.